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Cosmetics raw material Skin Whitening CAS 1197-18-8 Amstat Tranexamic Acid Powder
≥1 Kilogram
$110.00
- Item No. --MOQ 1 Kilogram
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| Amstat Chemical Properties | |
| Melting point | >300 °C(lit.) |
| Boiling point | 281.88°C (rough estimate) |
| density | 1.0806 (rough estimate) |
| refractive index | 1.4186 (estimate) |
| storage temp. | Store at 0°C |
| solubility | Freely soluble in water and in glacial acetic acid, practically insoluble in acetone and in ethanol (96 per cent). |
| form | Crystalline Powder |
| pka | pKa 4.3 (Uncertain);10.6 (Uncertain) |
| color | White |
| Water Solubility | 1g/6ml |
| Merck | 14,9569 |
| BRN | 2207452 |
| InChIKey | GYDJEQRTZSCIOI-LJGSYFOKSA-N |
| Product Name | Amstat | |
| Synonyms | amstat;amcha;amikapron;anvitoff;bay3517;cl65336;AMCA;HAKU | |
| CAS | 1197-18-8 |  |
MF | C8H15NO2 | |
| MW | 157.21 | |
| EINECS | 214-818-2 | |
| Product Categories | Building Blocks;C8;Carbonyl Compounds;Carboxylic Acids;Chemical Synthesis;Organic Building Blocks;-;4-Substituted Cyclohexanecarboxylic Acids;API's;API;CYKLOKAPRON;Cosmetics;Hemostatic;Pharmaceutical raw materials;Amines;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediates | |
| Amstat Usage And Synthesis | |||||||||
| Properties | Amstat is an antifibrinolytic drug, commonly called Tranexamic acid. Tranexamic acid is a white crystalline powder. It is freely soluble in water and in glacial acetic acid and is very slightly soluble in ethanol and practically insoluble in ether. | ||||||||
| Coagulation and hemostasis drugs | Tranexamic acid is a derivative of aminomethylbenzoic acid, and a kind of antifibrinolytic drugs to stop bleeding. The hemostasis mechanism of tranexamic acid is similar to aminocaproic acid and aminomethylbenzoic acid, but the effect is stronger. The strength is 7 to 10 times of aminocaproic acid, 2 times of aminomethylbenzoic acid, but toxicity is similar. The chemical structure of tranexamic acid is similar to lysine, competitive inhibition of plasmin original in fibrin adsorption, to prevent their activation, protection fiber protein not to degrade by plasmin and dissolve, eventually achieve hemostasis. Applicable in the treatment of acute or chronic, localized or systemic primary fiber fibrinolytic hyperthyroidism caused by bleeding, such as obstetric hemorrhage, renal hemorrhage, hemorrhage of hypertrophy of the prostate, hemophilia, pulmonary tuberculosis hemoptysis, stomach bleeding, after operation of liver, lung, spleen and other viscera hemorrhage; also can be used in surgery when abnormal bleeding etc.. Clinical tranexamic acid has effect significantly to insect bites disease, dermatitis and eczema, simple purpura, chronic urticaria, artificial sex urticaria, toxic eruption and eruption. And also has a certain effect on erythroderma, scleroderma, systemic lupus erythematosus (SLE), Erythema multiforme, shingles and alopecia areata. Treatment of hereditary angioedema effect is also good. In the treatment of Chloasma, general medicine is effective about 3 weeks, markedly effective 5 weeks, a course of 60 days. Given orally in doses of 0.25 ~ 0.5 g, a day 3 ~ 4 times. A few patients can nausea, fatigue, pruritus, abdominal discomfort, and diarrhea side effects after withdrawal symptoms disappear. | ||||||||
| Indications |
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| Mechanism of action | Tranexamic acid is a synthetic lysine amino acid derivative, which diminishes the dissolution of hemostatic fibrin by plasmin. In the presence of tranexamic acid, the lysine receptor binding sites of plasmin for fibrin are occupied, preventing binding to fibrin monomers, thus preserving and stabilizing fibrin’s matrix structure. | ||||||||
| Pharmacokinetics | After a single oral administration of two 650 mg tablets of LYSTEDA, the peak plasma concentration (Cmax ) occurred at approximately 3 hours (Tmax ). The absolute bioavailability of LYSTEDA in women aged 18-49 is approximately 45%. Following multiple oral doses (two 650 mg tablets three times daily). administration of LYSTEDA for 5 days, the mean C max increased by approximately 19% and the mean area under the plasma concentration-time curve (AUC) remained unchanged, compared to a single oral dose administration (two 650 mg tablets). Plasma concentrations reached steady state at the 5th dose of LYSTEDA on Day 2. | ||||||||
| Side effects | The table below contains some of the side-effects associated with tranexamic acid, although these occur only rarely.
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| Chemical Properties | White or almost white, crystalline powder. | ||||||||
| Uses | Antifibrinolytic agent; blocks lysine binding sites of plasminogen. Hemostatic. | ||||||||
| Uses | Used as lysine analogue to characterize binding sites in plasminogen | ||||||||
| Uses | Fibrinolysis, the cleavage of fibrin by plasmin, is a normal step in the dissolution of fibrin clots after wound repair. Tranexamic acid is an inhibitor of fibrinolysis that blocks the interaction of plasmin with fibrin (IC50 = 3.1 μM). It is a lysine mimetic that binds the lysine binding site in plasmin. Antifibrinolytic agents have value when fibrinolytic activity is abnormally high or when coagulation is impaired. | ||||||||
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Hot Tags: Tranexamic acid Tranexamic acid powder Tranexamic acid Whitening tranexamic acid amstat
| Business Type | Trading Company | Country / Region | Jiangsu, China |
| Main Products | NMN,Alpha Arbutin,Glutathione,Hyaluronic Acid,Kojic Acid | Total Employees | 11 - 50 People |
| Total Annual Revenue | US$2.5 Million - US$5 Million | Year Established | 2015 |
| Certifications | Product Certifications | ||
| Patents | Trademarks | Greenway | |
| Main Markets | Southeast Asia 20% Oceania 10% Africa 10% | ||
GREENWAY is a global operator of functional food and cosmetic ingredients based in Suzhou, China.
Founded in 2015, we represent two of China's leading manufacturers in the industry. Our ISO/GMP certified production facilities and high standard R&D center help ensure clients the excellent quality of our products.
We also provide ingredients sourcing service for clients upon the request.
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